Reprogramming Huntington Monkey Skin Cells into Pluripotent Stem Cells
نویسندگان
چکیده
منابع مشابه
Reprogramming Primordial Germ Cells into Pluripotent Stem Cells
BACKGROUND Specification of primordial germ cells (PGCs) results in the conversion of pluripotent epiblast cells into monopotent germ cell lineage. Blimp1/Prmt5 complex plays a critical role in the specification and maintenance of the early germ cell lineage. However, PGCs can be induced to dedifferentiate back to a pluripotent state as embryonic germ (EG) cells when exposed to exogenous signal...
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Induced pluripotent stem (iPS) cells have been derived from fibroblast, stomach, and liver cultures at extremely low frequencies by ectopic expression of the transcription factors Oct4, Sox2, c-myc, and Klf4, a process coined direct or in vitro reprogramming [1-8]. iPS cells are molecularly and functionally highly similar to embryonic stem cells (ESCs), including their ability to contribute to ...
متن کاملReprogramming of trophoblast stem cells into pluripotent stem cells by Oct4.
ESCs and trophoblast stem (TS) cells are both derived from early embryos, yet these cells have distinct differentiation properties. ESCs can differentiate into all three germ layer cell types, whereas TS cells can only differentiate into placental cells. It has not been determined whether TS cells can be converted into ES-like pluripotent stem (PS) cells. Here, we report that overexpression of ...
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Regenerative capacity of mammals is limited and can rarely regenerate a specific organ or tissue fully. Due to these limitations, regenerative medicine seeks efficient and safe cell sources for regeneration of damaged tissues and organs or treatment for incurable diseases. Human embryonic stem cells (HESCs) hold two important properties called self renewal and pluripotency. However, the use of ...
متن کاملSkin Stem Cells
The future development of medicine will greatly depend on research, knowledge and clinical application of stem cells. In recent years, stem cells especially; skin stem cells have been very interesting and amazing targets for study and scientific application in the following fields : 1- Cell-based therapy; 2- Regenerative medicine and tissue engineering; 3- Gene therapy; 4- Therapeutic cloning; ...
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ژورنال
عنوان ژورنال: Cellular Reprogramming
سال: 2010
ISSN: 2152-4971,2152-4998
DOI: 10.1089/cell.2010.0019